ACTIVATION OF THE NRF2/KEAP1 SIGNALING PATHWAY MEDIATES THE NEUROPROTECTIVE EFFECT OF PERILLYL ALCOHOL AGAINST CEREBRAL HYPOXIC-ISCHEMIC DAMAGE IN NEONATAL RATS

Neonatal hypoxic-ischemic encephalopathy (HIE) is a severe disease with a poor prognosis, whose clinical treatment is still limited to therapeutic hypothermia with limited efficacy.Perillyl alcohol (POH), a natural monoterpene found in various plant essential oils, has shown neuroprotective properties, though its effects on HIE are not well us polo

Over the last decades, the amount of data of all kinds available electronically has increased dramatically.Data are accessible through a range of interfaces including Web browsers, database query languages, application-specific interfaces, built on top of a number of different data exchange formats.All these data span from un-structured to highly s

The complex interplay of epigenetic factors is essential in regulating the hallmarks of cancer and orchestrating intricate molecular interactions during tumor progression.Circular RNAs (circRNAs), known for their covalently closed loop structures, are non-coding RNA molecules exceptionally resistant to enzymatic degradation, which enhances their st

Chitosan, a natural polymer derived from chitin by deacetylation process of chitin, has gained an enormous interest in tissue engineering due to its unique features such as antibacterial activity and wound healing properties.Electrospinning of acidified chitosan solution is one of the most widely-used approaches in fabrication of 3D scaffolds.Altho

BackgroundVaccines are one of the most important achievements of modern medicine.However, their acceptance is only partial, with vaccine hesitancy and refusal representing a major health threat.Influenza vaccines have low compliance since repeated, annual vaccination is required.Influenza vaccines stimulate discussions both in the real world and on